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The 5 year predicted absolute breast cancer risk accounts for multiple risk factors in an individual and should provide the best estimate of individual benefit (see INDICATIONS AND USAGE).
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We review the growing body of evidence which demonstrates immunomodulatory effects of tamoxifen, including in vitro and in vivo studies as well as observations made in breast cancer patients treated with tamoxifen.
For cosmetic and adverse-effect end points, at each assessment, patients' ratings in the two groups were compared with the use of the t-test for independent samples.
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According to a 1978 study in Cancer Treatment Reports and another published in Cancer in 1992, about six per cent of women taking even low-dose tamoxifen suffer damage to the retina and corneal opacities and decreased visual acuity.
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Our study is an international, intergroup, phase 3, randomized, double-blind trial comparing the efficacy and safety of continued adjuvant tamoxifen therapy with the efficacy and safety of exemestane therapy in postmenopausal women with primary breast cancer who remain free of disease after receiving adjuvant tamoxifen therapy for two to three years.
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Tamoxifen also is metabolized by CYP3A4, but because CYP2D6 is the enzyme responsible for producing the active metabolites, inhibition of CYP3A4 activity does not appear to be as important as CYP2D6.
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